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Q192R polymorphism of PON-1 gene in type 2 diabetic patients

Gorshunska M., Karachentsev Y., Atramen-tova L., Tyzhnenko T., Kravchun N., Pochernyaev A., Poltorak V.

 


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Polymorphism of PON-1 gene in 192 position of amino acid sequence of enzyme paraoxonase 1 was studied. For this research we have used the blood samples of 96 patients with T2DM and 123 healthy habitants of Kharkiv. Frequencies of alleles for the patients (рQ = 0,65, рR = 0,35) and the healthies (рQ = 0,70 and рR = 0,30) did not differentiate meaningfully. Distribution of the genotypes for healthy people does not correspond to Hardy-Weinberg equilibrium, the patients of T2DM have surplus of both homozygotes and shortage of heterozygotes. The risk of illness of T2DM for QQ homozygotes is 1,46-times higher and for QR heterozygotes is two times lower than on the average in the population (2 %). The risk of illness of T2DM for RR homozygotes 1,86-times exceeds a middle population risk but is not significant.

Tsitologiya i Genetika 2011, vol. 45, no. 1, pp. 48-51

E-mail: atramentova yandex.ru

Gorshunska M., Karachentsev Y., Atramen-tova L., Tyzhnenko T., Kravchun N., Pochernyaev A., Poltorak V. Q192R polymorphism of PON-1 gene in type 2 diabetic patients, Tsitol Genet., 2011, vol. 45, no. 1, pp. 48-51.

In "Cytology and Genetics":
M. Yu. Gorshunskaya, Yu. I. Karachentsev, L. A. Atramentova, T. V. Tyzhnenko, N. A. Kravchun, A. K. Pochernyaev, V. V. Poltorak Q192R polymorphism of PON-1 gene in type 2 diabetes patients, Cytol Genet., 2011, vol. 45, no. 1, pp. 38-40
DOI: 10.3103/S0095452711010087


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