ISSN 0564-3783  



Main page
Contacts
Preview papers  
Themes
Contents  
Themes
Subscription
Information to authors
Editorial board
Mobile version


In Russian

Export citations
UNIMARC
BibTeX
RIS





Graves disease: heredity peculiarities and selection impact on its prevalence in population

Shtandel S.A., Gopkalova I.V., Khaziev V.V., Du- Bovik V.N., Svetlova-Kovalenko Ye.A.

 


[Free Full Text (pdf)]Article Free Full Text (pdf)  

On genealogic data about 242 Graves disease patients, fertility parameters of 2105 healthy and 369 Graves disease women peculiarities of genetic determination and natural selection of disease were studied. Results of the genetic analysis have revealed conformity of Graves disease inheritance to alternative model parameters. Homozygote penetrance within the framework of this model was 78,8 %, heterozygote - 17,3 %. For one generation in the Kharkov area population frequency of a gene to Graves disease predisposition increases 0,8 %.

Tsitologiya i Genetika 2009, vol. 43, no. 2, pp. 65-71



Shtandel S.A., Gopkalova I.V., Khaziev V.V., Du- Bovik V.N., Svetlova-Kovalenko Ye.A. Graves disease: heredity peculiarities and selection impact on its prevalence in population, Tsitol Genet., 2009, vol. 43, no. 2, pp. 65-71.




Copyright© ICBGE 2002-2017 Coded & Designed by Volodymyr Duplij Modified 27.05.17