TSitologiya i Genetika 2020, vol. 54, no. 5, 39-44
Cytology and Genetics 2020, vol. 54, no. 5, 408–412, doi: https://www.doi.org/10.3103/S0095452720050060

Effect of gene SFU1 on the riboflavin synthesis in flavinogenic yeast Candida famata

Petrovska Y., Lyzak O., Dmytruk K., Sibirny A.

  1. Institute of Cell Biology National Academy of Sciences of Ukraine, Drahomanov St., 14/16, Lviv, 79005, Ukraine
  2. Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
  3. University of Rzeszow, Zelwerowicza 4, 35-601 Rzeszow, Poland

SUMMARY. Riboflavin or vitamin B2 is a necessary component for all living organisms being the precursor of flavin coenzymes FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide) involved in numerous enzymatic reactions. Flavinogenic yeast Candida famata overproduces riboflavin under iron starvation; however, regulation of this process is poorly understood. Regulatory gene SEF1 encoding transcription activator has been identified. Its deletion blocks yeast ability to overproduce riboflavin under iron starvation. It is known that in the pathogenic flavinogenic yeast C. albicans, Sfu1 (GATA-type transcription factor) represses SEF1. Here we found that deletion of SFU1 gene in wild type C. famata leads to riboflavin oversynthesis.

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TSitologiya i Genetika
2020, vol. 54, no. 5, 39-44

Current Issue
Cytology and Genetics
2020, vol. 54, no. 5, 408–412,
doi: 10.3103/S0095452720050060

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