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Expression of Bcl2 in imprint smears of endometrial carcinoma

Kosmas Konstantinos, Mitropoulou Georgia, Stamoulas Marios, Klapsinou Eirini, Marouga Anna


The aims of this study were to determine the expression of Bcl-2 in endometrial adenocarcinomas in imprint smears as an alternative technique rather than the frozen section and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period. One hundred two cases were type I and 24 type II endometrial adenocarcinomas. Positive expression of Bcl-2 was observed only in type I and in low grade carcinomas. Immunocytochemical findings from Bcl-2 stain, appeared to be a valuable predictor of endometrial cancer diagnosis and postoperative prognosis in most cases in endometrial cytology with imprint smears. Furthermore, positive expression of Bcl-2 was related to morphologic features of less aggressiveness (pathogenetic type I, low-grade, early advanced stage, deep myometrial involvement <1/2 or not) tumors.

Key words: Endometrial carcinoma, Bcl-2, imprint cytology, immunocytochemistry, endometrial cancer diagnosis

Tsitologiya i Genetika 2020, vol. 54, no. 4, pp. 93-95

  1. Department of Cytopathology, General Chest Diseases Hospital of Athens SOTIRIA, Greece
  2. Pathology Department, Agia Sofia Childrens Hospital of Athens, Greece
  3. Department of Obstetrics & Gynaecology, Chesterfield Royal Hospital, Derbyshire, UK
  4. Department of Cytology, Diagnostic and Therapeutic Center of Athens Hygeia, Athens, Greece
  5. Department of Cytopathology, Athens University, Medical School, Attikon University Hospital, Athens, Greece

E-mail: kosmas_konstantinos, mitropoulougeorgia, mdstamoulas, marougaanna yahoo.greirini_kl,

Kosmas Konstantinos, Mitropoulou Georgia, Stamoulas Marios, Klapsinou Eirini, Marouga Anna Expression of Bcl2 in imprint smears of endometrial carcinoma, Tsitol Genet., 2020, vol. 54, no. 4, pp. 93-95.

In "Cytology and Genetics":
Kosmas Konstantinos, Mitropoulou Georgia, Stamoulas Marios, Klapsinou Eirini & Marouga Anna Expression of Bcl-2 in Imprint Smears of Endometrial Carcinoma, Cytol Genet., 2020, vol. 54, no. 4, pp. 372378
DOI: 10.3103/S0095452720040064


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