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Molecular mechanisms of chondro- and osteogenesis disorders during osteoarthritis and the ways of correcting them

Torgomyan A.L., Saroyan M.Yu.

Review 

SUMMARY. The investigations, dedicated to the problem of regulating the process of chondrogenesis and cell engineering of the cartilage tissue, continue to be relevant nowadays, taking into consideration the degree of increasing incidence of osteodegenerative orthopedic diseases. The analysis of scientific literature was conducted to review molecular changes, developing in cartilage tissue during osteoarthritis (ОА). The search in international and domestic databases was performed by key words. Forty references, relevant to the topic, were selected. Many biological regulators were identified and analyzed for the possibility of including them into the processes of osteo- and chondrogenesis. The study of OA biomarkers and subsequent regulation of chondrogenesis using different molecules is the future of cartilage tissue cell engineering, aimed at restoring the cartilage, damaged by OA.

Key words: chondrocytes, stem cells, differentiation

Tsitologiya i Genetika 2020, vol. 54, no. 4, pp. 80-86

E-mail: adelinatorgomyan yahoo.com

Torgomyan A.L., Saroyan M.Yu. Molecular mechanisms of chondro- and osteogenesis disorders during osteoarthritis and the ways of correcting them, Tsitol Genet., 2020, vol. 54, no. 4, pp. 80-86.

In "Cytology and Genetics":
A. Torgomyan & M. Saroyan Molecular Mechanisms of Chondro- and Osteogenesis Disturbance in Osteoarthritis and Ways of Their Correction, Cytol Genet., 2020, vol. 54, no. 4, pp. 347–352
DOI: 10.3103/S0095452720040118

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