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Allelic polymorphism of the ATM gene and its contribution to formation of resistance to the action of adverse occupational factors
SUMMARY. The maintaining the integrity of DNA is an indispensable condition of the normal functioning of the cell. The role of polymorphism of DNA repair genes in formation of individual sensitivity of the genome to damaging mutagenic influences is actively studied. The purpose of the work was to study the distribution of frequency of genotypes of the gene of ATM (rs664677) in workers of hazardous and harmful industries for identification of risk markers to development of bronchopulmonary pathology. The study included workers of asbestos-cement plants and miners (n = 214). The genotypes of the gene of the ATM (rs664677) were determined in real time by the polymerase chain reaction method. The study revealed that the genotype ATM∙T/T is associated with the risk of developing bronchopulmonary pathology in the professional group of workers at asbestos cement plants (P = 0,02; χ2 = 4.98; OR = 3,47; 95% CI: 1,01–12,51) and miners (OR = 1,97; 95% CI: 0,70–5,53). Also, genotypes have been established that provide resistance to development of the respiratory system pathology: in the group of workers of asbestos-cement plants (ATM∙A/A (OR = 0,84; 95% CI: 0,45–1,58), ATM∙A/T (OR = 0,73; 95% CI: 0,41–1,33)) and for miners (ATM∙À/Ò (OR = 0,63 (0,28–1,43)). For the first time the obtained results point to importance of polymorphism of the gene of ATM (rs664677) of the Double – strand break repair in development of bronchopulmonary pathology in workers of hazardous and harmful industries of Ukraine.
Key words: SNP, ATM, bronchopulmonary pathology
E-mail: imp-cis ukr.net, morozless gmail.com, dosenko biph.kiev.ua
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