TSitologiya i Genetika 2016, vol. 50, no. 3, 36-41
Cytology and Genetics 2016, vol. 50, no. 3, 178–182, doi: https://www.doi.org/10.3103/S0095452716030063

Bcl1 polymorphism of glucocorticoid receptor gene in patients with bronchial asthma with obesity

Kmyta V.V., Garbuzova V.Y., Prystupa E.N., Prystupa L.N.

  • Sumy State University
  • Lviv State University of Physical Culture

The objective of this investigation was to analyze possible association between BclI polymorphism of glucocorticoid receptor gene and obesity in patients with bronchial asthma (BA). The study involved 188 patients with bronchial asthma and 95 apparently healthy adult individuals. Generally accepted assessments and examinations for BA diagnosis, and anthropometric, molecular-genetic and statistic methods of investigation were used in the research. It was found out that the patients with BA demonstrated higher body mass index (BMI) and higher ratio of fat centralization much more often, than the control group. Genotypes distribution for BclI polymorphism in patients with BA showed a statistically significant difference between patients with different BMI unlike the control group. Comparison of genotype frequency for BclI polymorphism in glucocorticoid receptor gene in individuals with different ratio of fat centralization in the control group and in the patients with BA separately showed statistically significant differences in the distribution of gene allelic variations only among the patients with BA. It was demonstrated that G/G genotype in the patients with visceral obesity was associated with BA.

Keywords: bronchial asthma, obesity, Вcl1 polymorphism, glucocorticoid receptor gene

TSitologiya i Genetika
2016, vol. 50, no. 3, 36-41

Current Issue
Cytology and Genetics
2016, vol. 50, no. 3, 178–182,
doi: 10.3103/S0095452716030063

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