Fish-estimated Spontaneous level of chromosome aberrations in peripheral blood lymphocytes in persons of different ages

FISH-WCP method with fluorescent probes to chromosomes ## 1, 2, 4 was used for cytogenetical examination of two groups of men (middle age 23 and 53,5 years) who deny their deliberate contact with known or supposed mutagens. The wide inter-individual variability of the stable chromosome aberration frequencies in each group has been shown (0,006–0,014 and 0,006–0,025 per cell per genome-equivalent correspondingly). The trend of increasing of the mean-group level of one-way and two-way translocations during aging has been revealed (0,009 and 0,013 per cell per genome-equivalent, correspondingly).

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