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X chromosome inactivation patterns in elderly women aged over 70 years

Yurov I.Y., Villard L., Vorsanova S.G., Demidova I.A., Goyko E.A., Shal’nova S.A., Shkol’nikova M.A., Olferiev A.M., Yurov Y.B.

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In the present study we have analyzed X chromosome inactivation patterns in 40 women aged from 74 to 85 years (mean age 78 years). The control group was 36 women (mean age 30 years). The most common AR-assay was used to determine X-inactivation patterns (the study of methylation patterns of HpaII site in human androgen receptor gene (HUMARA) by quantative PCR). The age dependence of X-inactivation was not observed. We have detected skewed X-inactivation in three women among 40 (7.5%) elderly women comparing to two women among 36 (5.5%) women from control group. The difference was not found to be statistically significant. We made a suggestion that higher incidence of skewed X-inactivation in elderly women revealed by previous studies could occur due to some experimental ambiguities as heterogeneity of the group studied; inclusion of women having relatives with genetic abnormalities associated with skewed X-inactivation patterns; the difference of X chromosome inactivation skewing determination. We conclude that present study does not show X chromosome inactivation to be age dependent.

Tsitologiya i Genetika 2004, vol. 38, no. 4, pp. 49-54

Yurov I.Y., Villard L., Vorsanova S.G., Demidova I.A., Goyko E.A., Shal’nova S.A., Shkol’nikova M.A., Olferiev A.M., Yurov Y.B. X chromosome inactivation patterns in elderly women aged over 70 years, Tsitol Genet., 2004, vol. 38, no. 4, pp. 49-54.