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Estimation of Potential Mutagenic Activity of 24-Epibrassinolide

Voitovich A.M., Nadjaran L.A., Kotelenets A.I., Afonin V.Yu., Davidovsky A.G., Ushkov A.A., Gavrilenko N.V.

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Genotoxic effect of synthetic phytohormone analogue of steroid origin epibrassinolide was studied in in vitro- and in vivo-tests. Epibrassinolide did not display mutagenic properties in Ames’test (S. typhimurium, TA100) and DNA damaging activity test (DNA of phage λ). The rise in the level of polichromatophilous erythrocytes with micronuclei was observed in the micronuclear test at intraperitoneal epibrassinolide injection at the dose of 500 mg/kg that seems to be associated with disturbance of cell membrane permeability.

Tsitologiya i Genetika 2004, vol. 38, no. 6, pp. 49-53

Voitovich A.M., Nadjaran L.A., Kotelenets A.I., Afonin V.Yu., Davidovsky A.G., Ushkov A.A., Gavrilenko N.V. Estimation of Potential Mutagenic Activity of 24-Epibrassinolide, Tsitol Genet., 2004, vol. 38, no. 6, pp. 49-53.