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Genetic Study of Psoriasis in Kharkov Population

Atramentova L. A., Ryzhko P. P., Fedota A. M.

400 pedigrees of men and women suffering from psoriasis were analyzed. The segregation frequencies in progeny of two healthy (SF_N×N = 0.083) and one affected parent (SF_N×A = 0.147) permitted to reject monogenic model of psoriasis inheritance. Near 100 % heritability of this disease in the polygenic model allowed to suggest existence of main susceptible gene and to estimate parameters of monogenic model with incomplete penetration (p = 0.044, P₁ = 6.1 %, P₂ = 82.2 %). According to this model 0.189 % of Kharkov population residents are homozygous and 8.32 % are heterozygous carriers of psoriatic gene, 0.155 % residents suffering from psoriasis are heterozygotes and 0.508 % are heterozygotes. 23 % of individuals suffering from psoriasis are homozygotes and 77 % heterozygotes.

Tsitologiya i Genetika 2001, vol. 35, no. 1, pp. 74-78

Atramentova L. A., Ryzhko P. P., Fedota A. M. Genetic Study of Psoriasis in Kharkov Population, Tsitol Genet., 2001, vol. 35, no. 1, pp. 74-78.