400 pedigrees of men and women suffering from psoriasis were analyzed. The segregation frequencies in progeny of two healthy (SFN×N = 0.083) and one affected parent (SFN×A = 0.147) permitted to reject monogenic model of psoriasis inheritance. Near 100 % heritability of this disease in the polygenic model allowed to suggest existence of main susceptible gene and to estimate parameters of monogenic model with incomplete penetration (p = 0.044, P1 = 6.1 %, P2 = 82.2 %). According to this model 0.189 % of Kharkov population residents are homozygous and 8.32 % are heterozygous carriers of psoriatic gene, 0.155 % residents suffering from psoriasis are heterozygotes and 0.508 % are heterozygotes. 23 % of individuals suffering from psoriasis are homozygotes and 77 % heterozygotes.
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