TSitologiya i Genetika 1999, vol. 33, no. 3, 14-20
Cytology and Genetics , vol. , no. , , doi: https://www.doi.org/

The mutational spectra of gene p53 in different types of tumors

Glazko G.V., Rogozin I.B., Sozinov A.A.

The comparative analysis of the frequencies of nucleotide exchanges in mutational spectra of gene p53 (5-8 exons) between germline cancer-prone families (Li-Fraumeni syndrome), between somatic mutations in the tumors of different histogenesis and cell lines, obtained from them, was carried out. The nucleotide positions with high level of mutation events (mutational "hot spots"), typical for germline mutational spectra, tissue-specific patterns of their disappearing and appearing of new ones in solid tumors in vivo, nearly complete absence of "hot spots" in lymphomas and cell lines in vitro were revealed. The obtained results allowed to suggest, that one of the leading factor controlling hot-spots distribution in 5-8 exons of gene p53 is the specificity of cell division conditions in vivo and in vitro.

Keywords:

TSitologiya i Genetika
1999, vol. 33, no. 3, 14-20

Current Issue
Cytology and Genetics
, vol. , no. , ,
doi:

Full text and supplemented materials

References