The content of DNA in the oral mucosal epitheliocytes and the expression of oncofetal antigens on the peripheral blood T-lymphocytes of women with breast dysplasias

The DNA content in epitheliocytes of the mucous membrane of the oral cavity and expression of carcinoembryonic antigen and trophoblast-specific beta-1 glycoprotein on peripheral blood lymphocytes, peripheral blood T-lymphocytes subsets into three groups of patients: 1--diffusion mastopathy; 2--diffusion mastopathy with fibromyoma uteri and 3--fibroadenoma were studied. It was indicated that DNA content was higher in all groups in comparison with healthy women and it was shown that in contrast to healthy women, 45% of patients studied had abnormal rate of T-cells subsets, about 30% of them had abnormal expression of CEA and TSG on peripheral blood ly c49 mphocytes. The data obtained show the significant disbalance in the mechanisms of defence and compensation taking place in the organisms of patients with nonmalignant mammary

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