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Detection of chromosomal aneuploidies in human blastomeres using FISH increases success of IVF by improving the chances of embryo progress to delivery

Semikhodskii A., Ismayilova M.


SUMMARY. Efficiency of PGT-A have been studied in patients with previous IVF failure, recurrent pregnancy loss, idiopathic infertility and infertility due to other causes. More than 50 % of all embryos produced in four experimental and one control groups were found to be aneuploid. Aneuploidies of autosomes 15 and 18 and of both sex chromosomes were the ones most frequently observed. Most aneuploidies were detected in patients with previous IVF failure and idiopathic infertility. After selecting euploid embryos for transfer high clinical pregnancy rates were achieved in all study groups. In at least 30 % of patients in each study group IVF treatment coupled with PGT-A resulted in live birth. The highest live birth rate was observed in patients with recurrent pregnancy loss and previous IVF failure thus clearely demostrating the benefits of offering PGT-A as part of treatment for various types of infertility.

Key words: FISH, PGT-A, IVF, ART, Aneuploidy, Recurring pregnancy loss, Idiopathic infertility, IVF failure

Tsitologiya i Genetika 2022, vol. 56, no. 3, pp. 3-13

  1. Medical Genomics Ltd, London, United Kingdom, 134 Somerset Road, London, SW19 5HP, United Kingdom
  2. , 76, , AZ1006
  3. Medical Genomics Ltd, London, UK134 Somerset Road, London, SW19 5HP, UK Central Clinic Hospital76 Parliament Ave., Baku, Azerbaijan AZ1006

E-mail: andrei, mahiremk

Semikhodskii A., Ismayilova M. Detection of chromosomal aneuploidies in human blastomeres using FISH increases success of IVF by improving the chances of embryo progress to delivery, Tsitol Genet., 2022, vol. 56, no. 3, pp. 3-13.

In "Cytology and Genetics":
A. Semikhodskii & M. Ismayilova Detection of Chromosomal Aneuploidies in Human Blastomeres Using FISH Increases the Success of IVF by Improving the Chances of Embryo Progress to Delivery, Cytol Genet., 2022, vol. 56, no. 3, pp. 209217
DOI: 10.3103/S0095452722030124


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