SUMMARY. During the histological study, we detected degenerative changes in the cartilage tissue of rats with sodium monoiodoacetate-induced osteoarthritis and evaluated the effect of chondroitin sulfate and multiprobiotic preparation on healing processes: the absence of post-necrotic changes and fibrous elements with the co-administration of these drugs. Molecular analysis of rat cartilage tissue with experimental osteoarthritis revealed increased expression of Nos2 gene and decreased expression of Acan gene compared to the control group of animals indicating the activation of inflammatory and destructive processes in the tissue. By the combined administration of chondroitin sulfate and multiprobiotic under the same conditions, the expression pattern of Nos2 and Acan genes returned to control values, indicating the promising use of multiprobiotics as a substance that increases the anti-inflammatory and antioxidant action of this chondroprotector in osteoarthritis treatment.
Keywords: cartilage, osteoarthritis, rats, Nos2 and Acan gene expression, chondroprotector, multiprobiotic
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