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Differently green-synthesized CdS quantum dots: comparison of toxicity, antiproliferative effects and adhesion activity on human cells

Garmanchuk L.V., Nehelia A.O., Inomistova M., Khranovska N.M., Tolstanova G.M., Blume Ya.B., Yemets A.I.

 




Quantum dots (QDs) are typical II–VI semiconductor materials, owing to their unique optical properties and tunable photoluminescence, have received much interest in the field of electronic and biomedical applications. However, the cytotoxicity of QDs has become a major concern for their safe usage in bioimaging, intracellular delivery or tracking molecules and organells. We have previously developed a novel alternative approach for the production of CdS QDs extracellularly by the biological synthesis using bacteria Escherichia coli, fungi Pleurotus ostreatus and plant Linaria maroccana as biomatrices. Produced nanoparticles are stable and luminescent, have a range of sizes from 2 to 10 nm in diameter. In the present research we have evaluated cytotoxic/cytostatic effects, proliferative activity, adhesive potential of produced CdS nanoparticles using HeLa cells, tumor cells of human T-and B-lymphocytes, AGS cancer cell line by MTT-assay and flow cytometry methods. It has been found that QDs have reduced toxicity as compared to inorganic cadmium sulfide which makes them attractive as a new type of non-toxic luminescent probes for bioimaging applications in cytological studies.

Key words: Quantum dots, cadmium sulfide, cytotoxicity, cancer cells, proliferative activity, adhesive potential

Tsitologiya i Genetika 2019, vol. 53, no. 2, pp. 43-55

E-mail: liudmyla_garmanchuk ukr.net, marie0589 gmail.com, yemets.alla nas.gov.ua, nkhranovska ukr.net

Garmanchuk L.V., Nehelia A.O., Inomistova M., Khranovska N.M., Tolstanova G.M., Blume Ya.B., Yemets A.I. Differently green-synthesized CdS quantum dots: comparison of toxicity, antiproliferative effects and adhesion activity on human cells, Tsitol Genet., 2019, vol. 53, no. 2, pp. 43-55.

In "Cytology and Genetics":
L. V. Garmanchuk, M. N. Borovaya, A. O. Nehelia, M. Inomistova, N. M. Khranovska, G. M. Tolstanova, Ya. B. Blume, A. I. Yemets CdS Quantum Dots Obtained by “Green” Synthesis: Comparative Analysis of Toxicity and Effects on the Proliferative and Adhesive Activity of Human Cells, Cytol Genet., 2019, vol. 53, no. 2, pp. 132–142
DOI: 10.3103/S0095452719020026


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