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Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion

Storozhenko K.V., Shkarupa V.M.

 




SUMMARY. The molecular-genetic testing of the polymorphic rs 2981579 (C > T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was conducted in 110 patients with mesial occlusion and in 103 general-population control subjects of Ukraine. Overall, we found rs2981579 polymorphism in the FGFR2 gene associated with mesial occlusion (OR = 1,67, 95 % CI = 1,14Ц2,45, р = 0,009). Compared to CC carriers, TT+CT carriers had a 3,21-fold increased odds of mesial occlusion (95 % CI = 1,57Ц6,57, P = 0.001). We found protective effect of the homozygous alelle C on mesial occlusion development (OR = 0,31, p = 0,001).This is the first published data on polymorphisms FGFR2 rs 2981579 (C>T) in patients with mesial occlusion.

Key words: mesial occlusion, gene polymorphism, FGFR2

Tsitologiya i Genetika 2017, vol. 51, no. 5, pp. 50-54

E-mail: Shkarupa_Vlad bigmir.net

Storozhenko K.V., Shkarupa V.M. Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion, Tsitol Genet., 2017, vol. 51, no. 5, pp. 50-54.

In "Cytology and Genetics":
K. V. Storozhenko, V. M. Shkarupa Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion, Cytol Genet., 2017, vol. 51, no. 5, pp. 361-364
DOI: 10.3103/S0095452717050103


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