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Effect of expression of IGF-1 gene on skin wound healing in K14/miGF-1 transgenic mice with streptozotocin-induced diabetes

Leonov Y., Shkumat M., Klymenko P., Hovorun M., Guzyk M., Kuchmerovska T., Pishel I.

 




SUMMARY. One of the main factors that can exert influence on the position and rate of skin regeneration process is IGF-1. Morphological and molecular biological studies of skin wounds of FVB wild-type mice and transgenic animals K14/mIGF-1 with streptozotocin-induced diabetes were carried out. An increase of IGF-1 expression, area and thickness of the regenerating epithelium, the number of Mac-1+ cells in the wound in transgenic animals compared with wild-type was shown.

Key words: skin, wound healing, diabetes, IGF-1, the expression

Tsitologiya i Genetika 2015, vol. 49, no. 1, pp. 26-34

E-mail: leonov geront.kiev.ua

Leonov Y., Shkumat M., Klymenko P., Hovorun M., Guzyk M., Kuchmerovska T., Pishel I. Effect of expression of IGF-1 gene on skin wound healing in K14/miGF-1 transgenic mice with streptozotocin-induced diabetes, Tsitol Genet., 2015, vol. 49, no. 1, pp. 26-34.




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