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Meiotic segregation of chromosomes 13 and 14 in sperm of heterozygous robertsonian translocation der(13;14) (q10; q10)

Pylyp L.Y., Spinenko L.A., Zukin V.D., Bilko N.M.

 


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SUMMARY. Meiotic segregation of chromosomes 13 and 14 was as-sessed by fluorescence in situ hybridization on sperm of five heterozygous carriers of the most frequent Robertsonian translocation der(13;14). Alternate segregation mode was predominant (mean 78,2 ± 5,7 %). The prevalence of balanced sperm varied from 69,4 to 86,5 %. Adjacent segregation mode was detected in 18,64 ± 4,90 % of sperm; 3:0 mode was detected in 2,48 ± 1,20 % of sperm. These results are informative for reproductive counseling of Robertsonian translocation der(13;14) carriers, providing information for assessment of probability of receiving normal/balanced embryos in assisted reproduction cycles.

Tsitologiya i Genetika 2014, vol. 48, no. 3, pp. 48-53

E-mail: l.pylyp ivf.com.ua

Pylyp L.Y., Spinenko L.A., Zukin V.D., Bilko N.M. Meiotic segregation of chromosomes 13 and 14 in sperm of heterozygous robertsonian translocation der(13;14) (q10; q10), Tsitol Genet., 2014, vol. 48, no. 3, pp. 48-53.

In "Cytology and Genetics":
L. Y. Pylyp, L. A. SpinenkoV. D. ZukinN. M. Bilko Meiotic segregation of chromosomes 13 and 14 in sperm of heterozygous Robertsonian translocation der(13;14)(q10;q10) carriers, Cytol Genet., 2014, vol. 48, no. 3, pp. 175–179
DOI: 10.3103/S0095452714030086


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