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Evaluation of cyto- and genotoxic action of ferronanomagnetic and constant magnetic field in in vivo system

Chekhun V.F., Lozovska Yu.V., Lukyanova N.Yu., Demash D.V., Todor I.N., Naleskina L.A.

 




SUMMARY. Cyto- and genotoxic effects of nanoparticles on the basis of FM, CMF or their combination have been studied in AKE cells, BM cells of erythroid line, and peripheral blood lymphocytes with the use of MN test and «DNA-comet» assay. It has been shown that expression of mentioned effects is related to FM concentration and duration of tested agent action. It has been also demonstrated that action of CMF alone in the studied cells did not cause any changes in cell architectonics or affect MN counts which are associated with DNA damage. When FM and CMF were used in combination there has been observed the phenomenon of induction of CMF action with FM nanoparticles. The obtained results allow recommend MN test and «DNA-comet» assay as the markers of genome stability in the tests of genotoxic effects of nanomaterials for development of vector nanosystems.

Tsitologiya i Genetika 2013, vol. 47, no. 3, pp. 60-70

E-mail: chekhun onconet.kiev.ua

Chekhun V.F., Lozovska Yu.V., Lukyanova N.Yu., Demash D.V., Todor I.N., Naleskina L.A. Evaluation of cyto- and genotoxic action of ferronanomagnetic and constant magnetic field in in vivo system, Tsitol Genet., 2013, vol. 47, no. 3, pp. 60-70.

In "Cytology and Genetics":
V. F. Chekhun, Yu. V. Lozovskaya, N. Yu. Lukyanova, D. V. Demash, I. N. Todor, L. A. Naleskina Assessment of the cyto- and genotoxic effects of a nanoferromagnetic and a static magnetic field in vivo, Cytol Genet., 2013, vol. 47, no. 3, pp. 179-187
DOI: 10.3103/S009545271303002X


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