ISSN 0564-3783  



Main page
Contacts
Preview papers  
Themes
Contents  
Themes
Subscription
Information to authors
Editorial board
Mobile version


In Russian

Export citations
UNIMARC
BibTeX
RIS





Radiation-induced modification of human somatic cell chromosomes sensitivity to the testing mutagenic exposure of bleomycin in vitro in lung cancer patients in delayed terms following chernobyl accident

Pilinskaya M.A., Dibskiy S.S., Dibskaya Y.B., Shvaiko L.I.

 




By using modified G2-bleomycin sensitivity assay above background level of cytogenetic effect considered as a marker of hidden chromosome instability (HCI) has been investigated in 3 groups liquidators of Chernobyl accident (occupational group 1), patients with lung cancer who denied conscious contact with ionizing radiation (group of comparison), liquidators with lung cancer (occupational group 2). Significant interindividual variations of cytogenetic effects induced with bleomycin and the lack of positive correlation between background and above background frequencies of chromosome aberrations have been shown in all observed groups. It had been established that occupational group 2 was the most burdened group by expression of the above background cytogenetic effect and, accordingly, number of persons with HCI. The data obtained permit to suggest the existence of the association between radiation-induced increase of individual sensitivity to testing mutagenic exposure and the realization of cancer in persons exposed to ionizing radiation. The results show acceptability of G2-bleomycin sensitivity assay under the cytogenetic examination of irradiated contingents for determining HCI as one of informative markers of predisposition to oncopathology.

Tsitologiya i Genetika 2012, vol. 46, no. 6, pp. 36-43

E-mail: pww ukr.net

Pilinskaya M.A., Dibskiy S.S., Dibskaya Y.B., Shvaiko L.I. Radiation-induced modification of human somatic cell chromosomes sensitivity to the testing mutagenic exposure of bleomycin in vitro in lung cancer patients in delayed terms following chernobyl accident, Tsitol Genet., 2012, vol. 46, no. 6, pp. 36-43.

In "Cytology and Genetics":
M. A. Pilinskaya, S. S. Dibskiy, E. B. Dibskaya, L. I. Shvaiko Radiation-induced modification of human somatic cells chromosome sensitivity to the testing mutagenic exposure of bleomycin in vitro in lung cancer patients in delayed terms following chernobyl accident, Cytol Genet., 2012, vol. 46, no. 6, pp. 360-365
DOI: 10.3103/S0095452712060084


Copyright© ICBGE 2002-2018 Coded & Designed by Volodymyr Duplij Modified 22.04.18