Lewis lung carcinoma variant with high sensitivity to antitumor antiangiogenic therapy reveals a high capacity to autophagy

SUMMARY. Comparative investigation of two variants of Lewis lung carcinoma cells (LLC and LLC/R9) growing under nutrient deficiency caused by long-term incubation without growth medium replacement was performed. It was established that LLC/R9 cells which in contrast to LLC cells had a high sensitivity to antitumor antiangiogenic therapy (AAT) revealed a high dependence of their survival from glucose level in growth medium as well as high capacity to autophagy under nutrient deficiency. Perhaps high autophagy activity in tumor cells may be considered as a marker of tumor AAT sensitivity.

Keywords: Lewis lung carcinoma, anticancer antiangiogenic therapy, metabolic stress, nutrient deficiency, autophagy