ISSN 0564-3783  



Main page
Contacts
Preview papers  
Themes
Contents  
Themes
Subscription
Information to authors
Editorial board
Mobile version


In Russian

Export citations
UNIMARC
BibTeX
RIS





The role of PPARs and his isoforms in the metabolic disorder related to insulin resistance and diabetes

Kravchenko N.A., Yarmish N.V.

Review 


[Free Full Text (pdf)]Article Free Full Text (pdf)  

PPARs play the key role in energy homeostasis, inflammation, development of insulin resistance, metabolic syndrome, therefore the special attention is spared to synthesis of the ligand PPARs (fibrates, thiazolidinediones). Three isoforms of PPARs are activated by the fatty acids and their derivatives Ц eukosanoides. Polymorphism of the Pro12Ala gene PPARG2 affects the sensitiveness of tissues to insulin and the risk of the development diabetes. It is assumed that the PPAR polymorphism is related to the differential answer on pharmacotherapy that is the foundation for development of the personification of the drug application and the estimate of prognosis.

Key words: polymorphism of PPARs gene, insulinoresistentance, obesity, diabetes, lipids

Tsitologiya i Genetika 2011, vol. 45, no. 3, pp. 68-77

E-mail: zventa1957 mail.ru, zventa1957 yandex.ru

Kravchenko N.A., Yarmish N.V. The role of PPARs and his isoforms in the metabolic disorder related to insulin resistance and diabetes, Tsitol Genet., 2011, vol. 45, no. 3, pp. 68-77.

In "Cytology and Genetics":
N. A. Kravchenko, N. V. Yarmysh Role of PPARs and their isoforms in metabolic disorders related to insulin resistance and diabetes, Cytol Genet., 2011, vol. 45, no. 3, pp. 191-199
DOI: 10.3103/S0095452711030042


Copyright© ICBGE 2002-2018 Coded & Designed by Volodymyr Duplij Modified 22.04.18