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Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell

Nersesyan A., Ilin A., Kulmanov M.

 


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A very promising antiviral and antimicrobial agent FS-1 was studied for its ability to induce DNA damage and micronuclei in human tumor cell lines HeLa and Caco-2 at concentrations of 200, 500 and 1000 mg/ml without exogenous metabolic activation. The compound was additionally tested for DNA damaging ability in human lymphocytes at concentrations of 200, 400 and 800 mg/ml. Neither DNA damage nor micronucleus formation was observed after treatment of all types of cells with FS-1. Based on these results, FS-1 can be further studied for its safety to humans for potential application in clinical medicine as an antimicrobial/antiviral drug.

Key words: DNA damage; tumor cell lines HeLa and Caco-2; human lymphocytes; comet assay

Tsitologiya i Genetika 2011, vol. 45, no. 2, pp. 10-15

  • National Center of Oncology, Yerevan, Armenia
  • Institute of Cancer Research, Medical University of Vienna, Austria
  • Scientific Center for Anti-Infectious Drugs, Almaty, Kazakhstan

E-mail: armen.nersesyan meduniwien.ac.at

Nersesyan A., Ilin A., Kulmanov M. Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell, Tsitol Genet., 2011, vol. 45, no. 2, pp. 10-15.

In "Cytology and Genetics":
A. Nersesyan, A. Ilin, M. Kulmanov Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell, Cytol Genet., 2011, vol. 45, no. 2, pp. 70-74
DOI: 10.3103/S0095452711020101


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