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Association of P-mobile element activity and DNA methylation pattern changes at the conditions of Drosophila melanogaster prolonged irradiation

Kravets A.P., Mousseau T.A., Litvinchuk A.V., Ostermiller S.

 


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Association of the radiosensitivity and epigenetic pattern DNA changes at the conditions of prolonged irradiation was investigated. Two laboratory Drosophila melanogaster strains (Canton-s and ri) irradiated for 20 generations to low doses rate (1,2 · 10–8, 0,8 · 10–8 and 0,12 · 10–8 Gy/s) were used as experimental objects. DNA for the analysis was extracted separately for the flies of males and females. Restriction endonucleases GluI, GlaI were used. Restriction analysis has shown that there are different DNA methylated patterns for males and females as for control and exposed variants. At the chronic irradiation there was the decline of methylation level at the enzymes GluI, GlaI sites recognition.

Tsitologiya i Genetika 2010, vol. 44, no. 4, pp. 29-33

E-mail: kravetsap yahoo.com

Kravets A.P., Mousseau T.A., Litvinchuk A.V., Ostermiller S. Association of P-mobile element activity and DNA methylation pattern changes at the conditions of Drosophila melanogaster prolonged irradiation, Tsitol Genet., 2010, vol. 44, no. 4, pp. 29-33.




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