ISSN 0564-3783  



Main page
Contacts
Preview papers  
Themes
Contents  
Themes
Subscription
Information to authors
Editorial board
Mobile version


In Russian

Export citations
UNIMARC
BibTeX
RIS





Tumor-associated macrophages in the prospect of development of targeted cancer therapy

Skivka L.M., Gorbik G.V., Fedorchuk A.G., Pozur V.V.

Review 


[Free Full Text (pdf)]Article Free Full Text (pdf)  

Tumour-associated macrophages (TAM) make about 80 % a total stromal leucocytes in solid tumours. Phenotypic and functional plasticity of this cell population causes its dual effect on tumour grows. Exceptional role of TAM in tumour progression makes them an attractive targets for selective cancer therapy. In this review the main groups of TAM-oriented methods of cancer therapy directed on inhibition of tumour angiogenesis and reactivation of antitumour action of TAM are analysed.

Key words: tumor-associated macrophages, M1 and M2 macrophage phenotype , targeted cancer therapy

Tsitologiya i Genetika 2009, vol. 43, no. 4, pp. 71-82

E-mail: realmed i.com.ua

Skivka L.M., Gorbik G.V., Fedorchuk A.G., Pozur V.V. Tumor-associated macrophages in the prospect of development of targeted cancer therapy, Tsitol Genet., 2009, vol. 43, no. 4, pp. 71-82.




Copyright© ICBGE 2002-2017 Coded & Designed by Volodymyr Duplij Modified 27.05.17