Tavokina L.V., Baronova E.V., Sopko N.I.

The most frequent chromosomal abnormalities in patients with reproductive problems

Cytology and Genetics 2007, v 41, number 4, 48-55

Results of cytogenetic and molecular-cytogenetic inspection of 210 matrimonial pairs with the problems of reproduction are presented. Different types of chromosomal aberrations have been detected in the karyotypes of the patients in 46 (10,95 %) cases. Such structural chromosomal aberrations as pericentric inversions, Robertsonian translocations, balanced reciprocal translocations, and marker chromosomes as well prevailed the numerical chromosomal aberrations (89,13 and 10,87 % cases accordingly). In the general group of the inspected patients there were 19 cases (4,52 %) characterized by the low level of X and Y chromosome mosaicism. The authors suppose that the patients with the exposed chromosomal abnormalities need the differentiated approach at their treatment.