Yatsishina A.P., Pidpala O.V., Ruban T.P., Timoshchuk O.V., Lukash L.L

Cytomorphological charasteristics of a novel mouse cell line G1

Cytology and Genetics 2006, v 40, number 3, 49-58

Growth and morphological properties of a novel mouse cell line G1 have been investigated. It has been shown that cells of this cell line possess the ability of spontaneous transformation in vitro: the cells have unlimited growth in culture, grow in medium with a low serum content and form multilayer colonies on a cell monolayer and cell colonies inside agar. Using micronucleus test it has been revealed that cells of the G1 cell line possess different forms of aberrant mitosis. The results indicate the neoplastic G1 cell transformation with aberrant mitosis.