Kovalenko O.О., Kostetsky I.E., Lukash L.L.

The influence of albumin on the spontaneous mutations frequency in somatic mammalian cells in vitro

Cytology and Genetics 2005, v 39, number 4, 53-56

Human albumin is able to induce statistically significant increasing of the frequency of spontaneous mutations in the hprt locus in cultured somatic mammalian cells. The strait dependence of the mutagenic effect on the protein concentration has been shown. The products of albumin degradation reveal antimutagenic activity in the investigated test-system.