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Biomonitoring in Lymphocytes of Workers Contacting with Nickel Compounds, and Approach to Decreasing of Genetic Effects

Perminova I.N., Sinel'shchikova T.A., Alekhina N.I., Perminova E.V., Zasukhina G.D.

 




While examining the workers of the fire nickel production contacting preferably with insoluble and weakly soluble compounds of nickel, inhibition of DNA repair and increased level of chromosome changes (micronucleus test) were detected. Decreasing of micronucleus number, which was higher in smokers, and tendency to the stimulation of DNA repair synthesis were revealed after 1-month course of ascorbic acid (1g/day). A level of changes in chromosome structure in the control group was estimated using the index of sister chromatid exchanges (SCE): variation of initial values was in normal bounds (6–8 SCE per cell), after vitamin course it even slightly decreased. High individual variability of chromosome changes and susceptibility to ascorbic acid was found.

Tsitologiya i Genetika 2001, vol. 35, no. 3, pp. 59-66



Perminova I.N., Sinel'shchikova T.A., Alekhina N.I., Perminova E.V., Zasukhina G.D. Biomonitoring in Lymphocytes of Workers Contacting with Nickel Compounds, and Approach to Decreasing of Genetic Effects, Tsitol Genet., 2001, vol. 35, no. 3, pp. 59-66.




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