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Structural Characteristics of Osteopontin mRNA.

Berezovskaya O.P., Sidorenko A.P., Mukha D.V.

 




Conservatism of primary and secondary structure of osteopontin mRNA in vertebrates of various taxes was studied using computer analysis and blot-hybridization procedure. Relatively high rate of evolution of a nucleotide sequence of osteopontin gene was revealed. Formation of hairpin-loop structures by adjacent sequences and a high content of AU-pairs indicate more flexible structure of the mammalian osteopontin mRNA as compared with the avian one. It has been detected some AU-enriched regions in 3´-terminal untranslated sequences, which presence is characteristic for short-lived mRNA. Evolutionary conserved subsequences in 3´- and 5´-terminal regions were suggested to be determinants of RNA-protein interaction in cytoplasm.

Tsitologiya i Genetika 2001, vol. 35, no. 3, pp. 35-42



Berezovskaya O.P., Sidorenko A.P., Mukha D.V. Structural Characteristics of Osteopontin mRNA., Tsitol Genet., 2001, vol. 35, no. 3, pp. 35-42.




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