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The viral genome status studied under the conditions of a mixed infection in lymphoblastoid cells by adenovirus and the Epstein-Barr virus

Nosach L.N., Diachenko N.S., Povnitsa O.Iu., Smirnova I.A., Kishinskaia E.G., Butenko Z.A., Panasenko G.V.

 




Some indices have been studied which characterized the state c86 of Epstein-Barr virus genome and adenovirus in the implanted lines of lymphoblastoid cells of B and T phenotype under the mixed or monoinfection. It has been shown that super infection by type 2 adenovirus rather sharply affects the state of Epstein-Barr virus genome in the Raji cells containing integrated Epstein-Barr virus genome. The state of adenovirus genome in the studied cells is less subject to changes. Its early area is revealed by hybridization using DNA-DNA method in a form of two fragments of different intensity which is maximum in the Raji and Jurkat cells, which evidences for the more expressivity of adenovirus genome in these cells.

Tsitologiya i Genetika 1998, vol. 32, no. 4, pp. 82-88



Nosach L.N., Diachenko N.S., Povnitsa O.Iu., Smirnova I.A., Kishinskaia E.G., Butenko Z.A., Panasenko G.V. The viral genome status studied under the conditions of a mixed infection in lymphoblastoid cells by adenovirus and the Epstein-Barr virus, Tsitol Genet., 1998, vol. 32, no. 4, pp. 82-88.




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