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The effect of the lectin from Sambucus nigra inflorescences on spontaneous and alkylating agent-induced mutagenesis in mammalian somatic cells

Lukash LL, Karpova IS, Miroshnichenko OS, Tikhonova TN, Lylo VV, Man’ko VG, Sukhorada EM, Golynskaia EL

 




Data on separation of purified galactose-specific lectin as well as its two polypeptide chains from inflorescences of European elder Sambucus nigra are represented. Their molecule quaternary structure after the pattern a2 b2 is suggested. It was shown that purified protein in concentration 2.0 mg/ml had mutagenic activity and might enhance mutagenic effect of alkylating substance MNNG. Thus, preparations of lectin from inflorescences of European elder influenced on spontaneous and induced by the alkylating agent mutagenicity in mammalian somatic cells in vitro.

Tsitologiya i Genetika 1997, vol. 31, no. 5, pp. 52-60



Lukash LL, Karpova IS, Miroshnichenko OS, Tikhonova TN, Lylo VV, Man’ko VG, Sukhorada EM, Golynskaia EL The effect of the lectin from Sambucus nigra inflorescences on spontaneous and alkylating agent-induced mutagenesis in mammalian somatic cells, Tsitol Genet., 1997, vol. 31, no. 5, pp. 52-60.




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