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Diagnosis of Mosaic Forms of the Caryotype Anomalies in Clinical Cytogenetic Studies

Kuleshov N. P., Simonyan I. V.

 




Mosaicism cases have been statistically analyzed with the aim to develop a general scheme of the cytogenetic study. Using the Bernoulli formula it is shown that when P = 0.95 and proportion of clones is 10:90% and more 29 cells should be initially analyzed. If all the cells are of the same chromosomal constitution (m = 0) the mosaicism is rejected. Mosaicism is highly probable when m = 4 and more among n = 29. When m = 1, 2 or 3 the number of cells should be increased to 44 in accordance with calculations by the formula: 1--Cnm.pm.(1--p)n-m = P.

Tsitologiya i Genetika 1987, vol. 21, no. 1, pp. 60-63



Kuleshov N. P., Simonyan I. V. Diagnosis of Mosaic Forms of the Caryotype Anomalies in Clinical Cytogenetic Studies, Tsitol Genet., 1987, vol. 21, no. 1, pp. 60-63.




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